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KMID : 1007320080140020130
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Journal of the Korean Society of Menopause
2008 Volume.14 No. 2 p.130 ~ p.138
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The Endometrial Ultrasonographic Changes in Postmenopausal Breast Cancer Patients Taking Aromatase Inhibitors after Stopping of Tamoxifen Treatment
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Hwang Kyu-Ri
Choi In-Sil
Hwang Ki-Tae
Bai Kwang-Bum
Jun Hye-Won
Sung Jung-Yeob
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Abstract
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Objectives: The purpose of this study is to estimate the effect of aromatase inhibitors on endometrial thickness in postmenopausal breast cancer patients previously having long-term tamoxifen treatment.
Methods: Twenty-four postmenopausal breast cancer patients who had received adjuvant tamoxifen 20 mg/day were replaced by aromatase inhibitors. The last endometrial thickness measurement taken before stopping of tamoxifen treatment was prospectively compared with further transvaginal ultrasonography evaluations, performed following aromatase inhibitors up to 2 years.
Results: The last mean endometrial thickness was 5.63±3.39 mm before stopping of tamoxifen treatment decreased to a mean value of 2.78±0.99 mm after 6 months since replacement treatment with aromatase inhibitors (P＜0.001). A second ultrasonographic measurement performed in 20 patients after 12 months since replacement treatment with aromatase inhibitors showed further decline of mean endometrial thickness to 2.39±0.80 mm (P＜0.001). Also, there was a significant decrease in endometrial thickness after 24 months since replacement treatment with aromatase inhibitors compared with the last mean endometrial thickness before stopping of tamoxifen treatment in 11 patients (P＜0.001).
Conclusion: Switching from tamoxifen to aromatase inhibitors treatment in postmenopausal breast cancer patients may lead to a decrease in endometrial thickness.
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KEYWORD
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Tamoxifen, Aromatase inhibitor, Breast cancer, Endometrial thickness
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